What is the Origin of Gut-Brain Axis Endocrine Arm?

This term is a specific delineation within the comprehensive Gut-Brain Axis model, focusing solely on the endocrine signaling mechanisms rather than the vagal or immune pathways. The 'endocrine arm' emphasizes the role of circulating chemical messengers as the primary mode of communication in this context. Its scientific foundation lies in neuroendocrinology and gastroenterology.

What is the Mechanism of Gut-Brain Axis Endocrine Arm?

Enteroendocrine cells in the gut lumen release peptide hormones like GLP-1, peptide YY (PYY), and ghrelin in response to nutrient presence or absence. These hormones travel via the bloodstream to cross the blood-brain barrier or act on peripheral nerves, directly signaling to hypothalamic centers that control energy expenditure and satiety. This mechanism provides a rapid, metabolically sensitive feedback loop between the gut environment and central homeostatic regulation.

Gut-Brain Axis Endocrine Arm ∞ Area

Gut-Brain Axis Endocrine Arm

Meaning

The Gut-Brain Axis Endocrine Arm specifically denotes the bidirectional communication pathway between the gastrointestinal tract and the central nervous system mediated by gut-derived hormones. This hormonal signaling loop is a critical component of the broader axis, regulating satiety, appetite, mood, and stress response through the release of various neuropeptides. The integrity of this arm is vital for metabolic and psychological well-being.