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Gut Barrier Integrity Science

Meaning

Gut barrier integrity science is the specialized field of study focused on the structure and function of the intestinal epithelium, a single layer of cells that acts as a selective barrier separating the luminal contents of the gut from the systemic circulation. This science investigates the tight junctions between these cells, recognizing that compromised integrity, often termed “leaky gut,” can lead to the translocation of microbial products and undigested food particles, triggering systemic inflammation and hormonal dysregulation. Maintaining this barrier is critical for immune and endocrine health.