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Gut Barrier Integrity

Meaning

Gut barrier integrity refers to the structural and functional soundness of the intestinal lining, which serves as a selective barrier between the contents of the gut lumen and the underlying circulatory and immune systems. This integrity is primarily maintained by a single layer of epithelial cells connected by tight junctions. When this barrier is robust, it efficiently absorbs nutrients while strictly excluding pathogens, toxins, and undigested food particles. A compromised barrier, often referred to as “leaky gut,” can lead to chronic low-grade systemic inflammation, which profoundly impacts hormonal balance and overall health.