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GSTM1 Null Variant

Meaning

The GSTM1 Null Variant refers to a specific genetic polymorphism where an individual is homozygous for the deletion of the Glutathione S-Transferase Mu 1 (GSTM1) gene. This common genetic profile results in the complete absence of the functional GSTM1 enzyme, which is a key component of the Phase II detoxification system in the liver and other tissues. Lacking this enzyme can alter the body’s capacity to process and excrete various compounds, including specific hormone metabolites.