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GSTM1-null

Meaning

GSTM1-null describes a specific genetic polymorphism where an individual lacks the functional Glutathione S-Transferase Mu 1 (GSTM1) gene due to a homozygous gene deletion. This common genetic variation results in a complete absence of the corresponding GSTM1 enzyme, which is vital for Phase II detoxification processes in the liver and other tissues. Individuals with this null genotype may exhibit a significantly reduced capacity to metabolize and excrete certain environmental toxins and endogenous hormone metabolites, impacting their overall health.