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GSTM1

Meaning

GSTM1 is the abbreviation for Glutathione S-Transferase Mu 1, a critical phase II detoxification enzyme encoded by the GSTM1 gene, which plays a pivotal role in conjugating glutathione with various endogenous and exogenous toxins, including hormone metabolites. Genetic variations, specifically a common null polymorphism where the gene is entirely deleted, can significantly reduce the body’s capacity for detoxification and clearance of harmful compounds. This enzyme’s activity is particularly relevant in hormonal health, as it affects the efficient elimination of estrogen metabolites, influencing overall endocrine balance and cellular protection.