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GSK-3β

Meaning

GSK-3β, or Glycogen Synthase Kinase-3 beta, is a serine/threonine protein kinase that acts as a central regulatory node in numerous intracellular signaling pathways, including those critical for glucose metabolism and neuronal function. In the context of hormonal health, this enzyme is a key mediator in insulin signaling, where its activity is typically inhibited by insulin to promote glycogen synthesis. Dysregulation of GSK-3β activity is implicated in states of insulin resistance, type 2 diabetes, and neurodegenerative conditions that often accompany hormonal decline. Therefore, its precise modulation is a focus for therapeutic interventions.