What is the Origin of Growth Hormone Stimulants?

The concept originated from the discovery of Growth Hormone-Releasing Hormone (GHRH) and Ghrelin, the two main hypothalamic peptides that regulate hGH release. The development of synthetic secretagogues was an effort to find therapeutic agents that could safely mimic or amplify these natural signaling pathways.

What is the Mechanism of Growth Hormone Stimulants?

These stimulants typically operate by binding to specific receptors in the pituitary, such as the Growth Hormone Secretagogue Receptor (GHSR), thereby mimicking the action of ghrelin or GHRH. This action triggers the pituitary to release a bolus of hGH into the bloodstream. The mechanism leverages the body's own regulatory feedback loops, often resulting in a more physiological release pattern compared to exogenous hGH administration.

Growth Hormone Stimulants ∞ Area

Growth Hormone Stimulants

Meaning

Growth Hormone Stimulants are a class of compounds, often peptides or amino acids, designed to enhance the pulsatile secretion of endogenous Human Growth Hormone (hGH) from the anterior pituitary gland. Unlike direct hormone replacement, these agents work by signaling the body’s natural production and release mechanisms. They are clinically utilized to support metabolic function, body composition, and tissue repair, particularly in the context of age-related somatopause.