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Growth Hormone Secretion Patterning

Meaning

Growth hormone secretion patterning refers to the natural, highly pulsatile rhythm of Growth Hormone (GH) release from the anterior pituitary gland, which is characterized by multiple small pulses throughout the day and a large, dominant secretory burst during the early stages of deep sleep. This specific temporal pattern, rather than just the total daily amount, is crucial for GH’s biological efficacy, influencing its downstream effects on Insulin-like Growth Factor 1 (IGF-1) production and overall anabolic signaling. Maintaining an optimal, youthful patterning is a key strategy for supporting lean body mass, bone mineral density, and metabolic homeostasis.