Question 1

What is the Meaning of Growth Hormone Secretagogues (GHS)?

Accepted Answer

Growth Hormone Secretagogues (GHS) are a class of compounds that stimulate the pituitary gland to secrete endogenous Growth Hormone (GH). These agents act as agonists for the ghrelin receptor, also known as the Growth Hormone Secretagogue Receptor (GHSR). Unlike direct GH replacement, GHS work by enhancing the body's natural pulsatile release of GH, offering a physiological approach to modulating the somatotropic axis. They are clinically investigated for conditions like GH deficiency and age-related body composition changes. Examples include compounds like ghrelin mimetics and certain peptides.

Question 2

What is the Origin of Growth Hormone Secretagogues (GHS)?

Accepted Answer

The term is derived from the Greek word secretagogos, meaning "to lead to secretion." The concept originated with the discovery of ghrelin, the endogenous ligand for the GHSR, which revealed a novel regulatory pathway distinct from Growth Hormone-Releasing Hormone (GHRH). This discovery led to the synthesis of non-natural, potent small molecules and peptides that could mimic ghrelin's action.

Question 3

What is the Mechanism of Growth Hormone Secretagogues (GHS)?

Accepted Answer

GHS primarily exert their effect by binding to and activating the GHSR on the somatotroph cells in the anterior pituitary gland and in the hypothalamus. This binding initiates a signaling cascade that dramatically increases the frequency and amplitude of GH pulses released from the pituitary. By stimulating the pituitary's own machinery, GHS aim to maintain the physiological pattern of GH secretion, which is distinct from the steady state achieved with exogenous GH administration.

Growth Hormone Secretagogues (GHS)

Meaning

Origin

Mechanism

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