The positive physiological and clinical outcomes derived from administering compounds that stimulate the body’s own pituitary gland to release endogenous Growth Hormone (GH). These benefits include improved body composition, characterized by reduced visceral adiposity and increased lean muscle mass. Patients often report enhanced sleep quality, accelerated tissue repair, and overall improved vitality and metabolic profile.
Origin
The therapeutic use of Growth Hormone Secretagogues (GHSs) emerged from decades of research into the hypothalamic control of the somatotropic axis, specifically the discovery of Growth Hormone-Releasing Hormone (GHRH) and ghrelin. The concept gained clinical relevance as a less invasive alternative to exogenous GH injection for addressing age-related somatopause. This approach is rooted in restorative endocrinology.
Mechanism
GHSs primarily exert their effect by binding to specific receptors on the somatotroph cells of the anterior pituitary, mimicking the action of GHRH or ghrelin to stimulate the pulsatile release of GH. This endogenous release pattern is considered more physiological than exogenous administration. The subsequent rise in Insulin-like Growth Factor 1 (IGF-1) mediates many of the anabolic and metabolic benefits, including enhanced lipolysis and protein synthesis.
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