Growth Hormone Secretagogue Use involves the administration of compounds designed to stimulate the endogenous release of Growth Hormone (GH) from the anterior pituitary gland. These agents act by mimicking or potentiating the action of ghrelin or GHRH, thereby bypassing direct exogenous GH administration. This strategy aims to support anabolic processes and body composition naturally.
Origin
The term is derived from “Secretagogue,” meaning a substance that causes secretion, and “Growth Hormone,” the key anabolic peptide. Its modern application is rooted in understanding the regulation of the somatotropic axis and the clinical desire to support tissue repair and lean mass maintenance, especially in aging populations.
Mechanism
Secretagogues function by interacting with specific receptors, such as the ghrelin receptor (GHSR-1a) on somatotroph cells in the pituitary. This interaction signals the release of stored GH pulses, often leading to a more physiological pulsatile pattern compared to daily injections. Successful use requires careful timing relative to sleep and exercise to maximize the resulting anabolic signaling cascade.
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