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Growth Hormone Secretagogue Selectivity

Meaning

Growth Hormone Secretagogue Selectivity is the pharmacological characteristic defining the degree to which a Growth Hormone Secretagogue (GHS) preferentially stimulates the release of Growth Hormone (GH) from the anterior pituitary gland without significantly affecting the secretion of other pituitary hormones, such as Prolactin or Adrenocorticotropic Hormone (ACTH). Clinical relevance hinges on achieving the anabolic and lipolytic benefits of elevated GH and Insulin-like Growth Factor 1 (IGF-1) while minimizing the risk of adverse effects associated with the non-selective release of other endocrine factors. High selectivity is a hallmark of a precise and therapeutically superior GHS compound.