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Growth Hormone Secretagogue Differentiation

Meaning

The clinical and pharmacological classification and distinction among various compounds that stimulate the secretion of endogenous growth hormone (GH) from the pituitary gland, known as growth hormone secretagogues (GHSs). Differentiation is based on the specific receptor binding profile, the mechanism of action, the resulting pulsatility pattern of GH release, and the clinical safety and efficacy profile of each agent. This nuanced understanding is vital for selecting the most appropriate GHS for a patient’s specific therapeutic goal, whether it is body composition improvement or tissue repair.