What is the Meaning of Growth Hormone-Releasing Hormone?

Growth Hormone-Releasing Hormone, or GHRH, is a hypothalamic peptide hormone that acts as the primary physiological stimulator of Growth Hormone (GH) secretion from the anterior pituitary gland. This neurohormone plays a pivotal role in regulating somatotropic function across the lifespan, particularly during sleep and exercise. Its pulsatile release dictates the amplitude of subsequent GH pulses.

What is the Origin of Growth Hormone-Releasing Hormone?

The term describes its function directly: it releases growth hormone. It originates from neuroendocrinology, identifying the source (hypothalamus) and the target action (releasing GH). The native form is often referred to as Sermorelin or GHRH(1-29).

What is the Mechanism of Growth Hormone-Releasing Hormone?

GHRH travels via the hypophyseal portal system to the pituitary, where it binds to the GHRH receptor on somatotrophs. This binding initiates a signal transduction cascade, elevating intracellular calcium and cAMP levels, which are essential for packaging and releasing pre-synthesized GH vesicles into the systemic circulation. This signaling is intricately balanced by the inhibitory influence of Somatostatin.

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