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Growth Hormone Regulation

Meaning

Growth Hormone Regulation is the precise, pulsatile control of the synthesis and secretion of Growth Hormone (GH) from the anterior pituitary gland, a process that significantly influences body composition, bone density, and metabolic function throughout the lifespan. This regulation is primarily governed by the interplay of two hypothalamic hormones: Growth Hormone-Releasing Hormone (GHRH), which stimulates release, and Somatostatin (SRIF), which inhibits it. Optimal GH regulation is characterized by pronounced nocturnal pulses, crucial for tissue repair and anabolic processes. Age-related decline in this regulatory capacity, known as somatopause, is a major focus in longevity medicine.