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Growth Hormone Receptor Upregulation

Meaning

Growth Hormone Receptor Upregulation is the physiological process of increasing the number or sensitivity of Growth Hormone Receptors (GHRs) on the surface of target cells, primarily in the liver and peripheral tissues. This enhancement improves the body’s responsiveness to circulating Growth Hormone (GH), amplifying its anabolic and metabolic effects even if GH levels remain stable or only moderately increase. Clinical strategies often target this mechanism to maximize the biological efficacy of endogenous or administered GH.