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Growth Hormone Receptor Antagonist

Meaning

A Growth Hormone Receptor Antagonist (GHRA) is a pharmaceutical agent specifically engineered to block the biological actions of endogenous growth hormone (GH) at the cellular level. This class of drug is primarily utilized in the clinical management of acromegaly, a condition of GH hypersecretion, where it is crucial to normalize circulating levels of Insulin-like Growth Factor 1 (IGF-1) and mitigate tissue overgrowth. The antagonist acts by preventing the proper signal transduction that normally follows GH binding, thereby effectively rendering the body resistant to the excessive hormone.