The clinical application of synthetic peptide secretagogues that stimulate the body’s endogenous release of Growth Hormone (GH) from the pituitary gland, with the therapeutic goal of mitigating age-related physiological decline. These peptides are utilized to restore more youthful patterns of GH secretion, which naturally diminishes with age, without the risks associated with administering exogenous GH. The primary focus is on improving body composition, recovery, and vitality.
Origin
This practice evolved from the study of the somatotropic axis and the recognition that declining GH and Insulin-like Growth Factor 1 (IGF-1) levels are hallmarks of somatopause, a key component of human aging. The development of specific GH-releasing peptides (GHRPs) and Growth Hormone-Releasing Hormone (GHRH) analogues offered a more physiological and regulated approach than traditional GH replacement. This represents a targeted hormonal intervention in longevity medicine.
Mechanism
These peptides function by binding to specific receptors in the pituitary gland, such as the ghrelin receptor (GHRPs) or the GHRH receptor (GHRH analogues), stimulating the pulsatile release of GH. The released GH then acts on the liver and other tissues to induce the production of IGF-1, which mediates most of the anabolic and metabolic effects. The resulting physiological changes include enhanced protein synthesis, improved lipolysis, and increased bone mineral density, contributing to an anti-aging effect.
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