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Growth Hormone Inhibition

Meaning

Growth Hormone Inhibition refers to the physiological or pharmacological process of reducing the synthesis and secretion of Growth Hormone (GH) from the anterior pituitary gland. Physiologically, this process is a critical negative feedback loop mediated primarily by the hormone Somatostatin, which is released from the hypothalamus. Clinically, targeted inhibition may be necessary in conditions like acromegaly, where excessive GH leads to pathological overgrowth and metabolic complications. The careful modulation of GH secretion is a cornerstone of endocrine management, balancing its anabolic and lipolytic effects against the risks associated with chronic hypersecretion. Understanding the dynamics of inhibition is as important as understanding its stimulation.