What is the Origin of Growth Hormone Axis Support?

The term originates from pediatric endocrinology but is now widely applied in adult endocrinology and anti-aging medicine to address age-related GH deficiency (AGHD). 'Support' implies facilitating the axis's natural function rather than overriding it, focusing on upstream regulators and downstream signaling integrity. It acknowledges the axis as a coordinated feedback system.

What is the Mechanism of Growth Hormone Axis Support?

Support mechanisms focus on enhancing the amplitude and frequency of GHRH pulses from the hypothalamus and protecting somatotrophs in the anterior pituitary. Adequate sleep architecture and specific nutrient profiles, such as elevated arginine or ornithine, can positively influence pulsatile release. Furthermore, mitigating factors that induce GH resistance, like high visceral adiposity, is integral to effective support.

Growth Hormone Axis Support

Meaning

Growth Hormone Axis Support encompasses therapeutic and lifestyle strategies aimed at optimizing the entire somatotropic axis, spanning from hypothalamic GHRH release to pituitary GH secretion and subsequent IGF-1 generation in peripheral tissues. This support is essential for maintaining lean body mass, bone mineral density, and metabolic efficiency, especially with advancing age. It requires synchronizing the pulsatile release pattern.