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Growth Factor Signaling Integrity

Meaning

This describes the state of optimal function and responsiveness within the complex cellular communication network mediated by growth factors, which are polypeptide hormones regulating cell proliferation, differentiation, survival, and tissue repair. Maintaining integrity means that the synthesis, precise receptor binding, and intracellular signal transduction of these factors, such as Insulin-like Growth Factor 1 (IGF-1) and Fibroblast Growth Factors (FGFs), are robust and perfectly balanced. This specific signaling is paramount for youthful tissue remodeling, skin health, and effective metabolic adaptation. Compromised integrity is a key molecular hallmark of biological aging and impaired regenerative capacity.