What is the Origin of Growth Factor Restriction?

This concept is rooted in the extensive research on caloric restriction and intermittent fasting, which demonstrated that reduced nutrient signaling extends lifespan in various organisms. It shifts the focus from simple calorie counting to the specific modulation of nutrient-sensing pathways. "Restriction" refers to the targeted dampening of the signaling cascade, not the complete elimination of growth factors.

What is the Mechanism of Growth Factor Restriction?

The primary mechanism involves the transient suppression of the Insulin/IGF-1 and mTOR pathways, which are typically activated by nutrient availability. Lowered signaling from these growth factors disinhibits key longevity pathways, such as the AMPK and sirtuin pathways. This shift in cellular signaling redirects energy away from growth and proliferation and towards stress resistance, mitochondrial biogenesis, and the removal of damaged cellular components through enhanced autophagy.

Growth Factor Restriction ∞ Area

Growth Factor Restriction

Meaning

Growth Factor Restriction is a therapeutic strategy involving the intentional and temporary downregulation of specific anabolic signaling pathways, such as the Insulin/IGF-1 axis, often achieved through dietary or pharmacological means. The clinical objective is to mimic the biological effects of nutrient scarcity, thereby activating cellular maintenance and repair processes, including autophagy and DNA repair. This strategic restriction is employed to enhance cellular resilience and promote longevity mechanisms.