This clinical strategy involves optimizing the function of the somatotropic axis, which primarily includes Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1), to promote tissue repair, cellular regeneration, and metabolic homeostasis. Support extends beyond mere replacement, focusing on enhancing the sensitivity and signaling efficiency across the entire endocrine cascade. A well-supported axis is central to maintaining youthful physiological resilience and functional integrity.
Origin
The concept is derived from endocrinology, specifically the study of the GH-IGF-1 axis and its pivotal role in development, metabolism, and the aging process known as somatopause. Clinical support protocols were developed to counteract the age-related decline in GH pulsatility and subsequent IGF-1 production. This intervention is a direct response to age-related endocrine atrophy.
Mechanism
Support is often achieved through GHRH analogs, GH Secretagogues, or specific nutrient cofactors that potentiate GH release from the pituitary or enhance IGF-1 receptor sensitivity at the cellular level. This enhanced signaling promotes protein synthesis, lipolysis, and improved glucose utilization, which collectively contribute to better body composition and tissue integrity. The goal is to maximize the trophic and metabolic benefits of the axis.
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