These are short chains of amino acids that function as critical signaling molecules, orchestrating various aspects of cellular growth, differentiation, repair, and metabolism throughout the body. Unlike classical hormones, many act locally (paracrine or autocrine), though some, like Growth Hormone-Releasing Peptide (GHRPs), exert systemic endocrine effects. They represent a sophisticated class of biological communicators essential for tissue maintenance and healthy aging.
Origin
The term is descriptive, combining “growth” to denote their primary function of stimulating cell proliferation and repair, “chemical signal” to identify their role in cellular communication, and “peptides” to specify their molecular structure as short protein fragments. This field of study emerged from the isolation and characterization of various growth factors and regulatory peptides in the mid-20th century.
Mechanism
These signal peptides bind to specific high-affinity receptors on the surface of target cells, triggering complex intracellular signaling cascades, often involving phosphorylation events. The downstream effects typically include the activation of genes responsible for protein synthesis, cell division, and tissue remodeling. Their regulatory influence is tightly controlled by feedback loops and enzymatic degradation, ensuring localized and transient action.
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