What is the Origin of GrimAge Clock?

Developed by Dr. Steve Horvath and colleagues, the GrimAge Clock builds upon the foundational work of the original Horvath clock, specifically integrating methylation markers associated with smoking, inflammation, and age-related mortality. The name is a direct reference to its predictive power regarding morbidity and mortality risk.

What is the Mechanism of GrimAge Clock?

The mechanism involves quantitative analysis of DNA methylation, a process where methyl groups are added to DNA, effectively turning genes on or off without altering the underlying genetic sequence. GrimAge focuses on methylation sites whose status is a proxy for the levels of certain blood proteins, such as PAI-1 and growth differentiation factor 15, which are known to be influenced by chronic inflammation and endocrine health. A lower GrimAge, relative to chronological age, suggests a healthier biological trajectory.

GrimAge Clock

Meaning

The GrimAge Clock is a sophisticated, second-generation epigenetic clock designed to estimate an individual’s biological age and predict lifespan more accurately than earlier chronological measures. This biomarker assesses methylation patterns at specific CpG sites across the genome, which are highly correlated with plasma protein levels and health-related risk factors, including those linked to hormonal and metabolic dysregulation. It is considered a powerful tool for quantifying the biological impact of lifestyle and clinical interventions on the aging process.