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Grey Matter Sparing

Meaning

Grey Matter Sparing is a clinical and physiological phenomenon referring to the preservation of the volume and integrity of the brain’s grey matter, which contains the cell bodies, dendrites, and synapses of neurons. This preservation is a crucial marker of cognitive reserve and neurological resilience against age-related decline and neurodegenerative processes. Sparing this tissue is directly correlated with better cognitive outcomes, including maintained executive function and processing speed, particularly in the later stages of life. It is a tangible anatomical goal for longevity and neuro-optimization protocols.