Green Tea Catechins are a group of naturally occurring polyphenolic compounds, classified as flavonoids, which are highly abundant in green tea leaves and possess significant antioxidant and anti-inflammatory properties. Epigallocatechin gallate (EGCG) is the most potent and clinically relevant of these compounds, known for its profound effects on cellular signaling and metabolic health. These molecules act as powerful modulators within the human physiological system.
Origin
The term and the compounds themselves originate from the traditional consumption of Camellia sinensis (the tea plant), with their therapeutic properties recognized in traditional Asian medicine for centuries. Modern biochemistry isolated and identified these specific molecules, leading to extensive research into their pharmacokinetics and clinical applications. Their role is now studied within the context of metabolic and hormonal regulation.
Mechanism
The primary mechanism involves potent free radical scavenging activity, which reduces oxidative stress and subsequent cellular damage, thereby supporting mitochondrial function. Furthermore, catechins, particularly EGCG, act as modulators of key enzymes and signaling pathways, including inhibiting catechol-O-methyltransferase (COMT) to prolong the action of catecholamines and enhancing fatty acid oxidation. This multifaceted action supports improved insulin sensitivity and aids in the regulation of thermogenesis and energy expenditure.
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