What is the Origin of GRB10 Gene?

The gene was identified through molecular biology research focused on intracellular signaling cascades and the mechanisms of growth factor receptor function. Its designation, GRB10, reflects its role as a binding protein to growth factor receptors. Research into its imprinted expression patterns highlighted its critical role in balancing nutrient partitioning and growth regulation in mammalian physiology.

What is the Mechanism of GRB10 Gene?

The GRB10 protein functions primarily by binding directly to the activated tyrosine kinase domains of various receptor tyrosine kinases, including the insulin receptor and IGF-1 receptor. This binding sterically hinders or prevents the recruitment of other downstream signaling molecules, thereby interrupting the cascade that leads to metabolic actions like glucose uptake and protein synthesis. By inhibiting these pathways, the GRB10 gene product effectively modulates the cell's overall sensitivity to these critical metabolic hormones.

GRB10 Gene ∞ Area

GRB10 Gene

Meaning

The GRB10 gene, or Growth factor receptor-bound protein 10, encodes a signaling protein that acts as a negative regulator of several key growth factor and hormone signaling pathways, most notably those involving insulin and insulin-like growth factors (IGFs). This protein acts as a molecular brake, dampening the anabolic and metabolic effects of these hormones on target cells. Variations in the GRB10 gene have been clinically associated with altered fetal growth, insulin resistance, and metabolic syndrome, making it a relevant factor in managing hormonal health and metabolic wellness.