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GRB10

Meaning

GRB10, or Growth Factor Receptor-Bound Protein 10, is an adaptor protein that functions as a critical negative regulator within several key endocrine and metabolic signaling pathways. It is known to interact with and inhibit the signaling of various receptor tyrosine kinases, including the insulin receptor and insulin-like growth factor 1 (IGF-1) receptor. This protein plays a nuanced role in modulating cellular growth, metabolism, and glucose homeostasis, linking hormonal action to cellular energy status.