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Grapefruit Juice Interaction

Meaning

Grapefruit juice interaction is a clinically significant phenomenon where the consumption of grapefruit juice or the whole fruit can dramatically alter the pharmacokinetics of certain medications, including some hormonal therapies. This interaction typically leads to an increase in the circulating concentration of the drug, which can elevate the risk of dose-dependent side effects or toxicity. Patients undergoing specific hormonal treatments must be advised about this potential interaction to ensure therapeutic safety and efficacy.