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GPX4

Meaning

GPX4, or Glutathione Peroxidase 4, is a crucial selenium-containing enzyme responsible for protecting cell membranes from oxidative damage, particularly from lipid peroxides. It plays a pivotal role in cellular survival by neutralizing toxic lipid hydroperoxides, preventing a specific form of regulated necrotic cell death known as ferroptosis. The functional integrity of GPX4 is paramount for maintaining cellular homeostasis, especially in tissues with high metabolic activity.