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GPR43

Meaning

GPR43, which stands for G Protein-coupled Receptor 43, is a specific cell surface receptor predominantly found on immune cells and on specialized enteroendocrine cells located within the lining of the gut. This receptor functions as a critical molecular sensor for short-chain fatty acids (SCFAs), which are vital microbial metabolites produced through the fermentation of dietary fiber by the colonic microbiota. GPR43 serves as a key molecular bridge, directly integrating the activity of the gut microbiota with the host’s systemic metabolism, immune regulatory pathways, and critical hormonal signaling, particularly those governing energy balance and inflammatory status.