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GPER1

Meaning

GPER1, which is the abbreviation for G Protein-coupled Estrogen Receptor 1, is a non-classical, membrane-bound estrogen receptor that is responsible for mediating the rapid, non-genomic actions of estrogen, independent of the traditional nuclear receptor signaling pathway. This receptor is expressed across a wide variety of tissues, including the cardiovascular system, breast, and brain, where it plays critical roles in rapid cellular responses such as vasodilation, cell migration, and proliferation. GPER1 provides an important alternative pathway for estrogen signaling and a distinct therapeutic target.