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Gonadotropin Signaling Preservation

Meaning

Gonadotropin Signaling Preservation is a therapeutic objective focused on maintaining the functional integrity of the signaling cascade initiated by gonadotropins, specifically Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), in the gonads (testes and ovaries). This preservation is crucial for sustaining endogenous hormone production, fertility potential, and the overall vitality of the hypothalamic-pituitary-gonadal (HPG) axis. In clinical practice, this often involves employing specific hormone modulation strategies that support the pituitary’s release of LH and FSH, rather than entirely replacing their downstream effects, thereby avoiding iatrogenic suppression of the natural feedback loop.