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Gonadorelin Use Rationale

Meaning

Gonadorelin Use Rationale refers to the clinical justification for administering Gonadorelin, a synthetic decapeptide identical to the naturally occurring Gonadotropin-Releasing Hormone (GnRH), often in the context of hormonal therapy. In male reproductive endocrinology, its rationale centers on its pulsatile administration to stimulate the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This approach is primarily used to restore or maintain endogenous testicular function and fertility during or after exogenous testosterone administration. The use is predicated on mimicking the body’s natural, rhythmic signaling pattern.