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Gonadorelin Enclomiphene Mechanism

Meaning

The Gonadorelin Enclomiphene Mechanism refers to a synergistic clinical strategy employing two distinct pharmaceutical agents to stimulate the Hypothalamic-Pituitary-Gonadal (HPG) axis, primarily for enhancing endogenous testosterone production. Gonadorelin, a synthetic form of Gonadotropin-Releasing Hormone (GnRH), directly stimulates the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). Enclomiphene, a selective estrogen receptor modulator (SERM), blocks the negative feedback of estrogen at the hypothalamus and pituitary, further augmenting LH and FSH release. This combination aims to restore hormonal balance while preserving testicular function.