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Gonadorelin Co-Therapy Rationale

Meaning

Gonadorelin Co-Therapy Rationale outlines the clinical justification for administering Gonadorelin, or Gonadotropin-Releasing Hormone (GnRH), concurrently with other hormonal agents, often as part of a fertility or endocrine optimization regimen. Gonadorelin is a decapeptide that stimulates the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary gland. The co-therapy is typically employed to mimic the body’s natural pulsatile hormone release, aiming to maintain or restore endogenous gonadal function during or following exogenous hormone administration. This strategy seeks to prevent iatrogenic suppression of the Hypothalamic-Pituitary-Gonadal (HPG) axis.