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Gonadorelin Clomiphene Enclomiphene

Meaning

This grouping refers to three distinct pharmacological agents utilized in hormonal health, primarily in males, to stimulate the body’s endogenous production of testosterone by modulating the hypothalamic-pituitary-gonadal (HPG) axis. Gonadorelin, a synthetic GnRH, stimulates the pituitary directly, while Clomiphene and its purified isomer, Enclomiphene, act as selective estrogen receptor modulators (SERMs) at the hypothalamus and pituitary. These agents are central to fertility preservation and restoring hormonal balance without introducing exogenous testosterone.