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Gonadorelin Axis Preservation

Meaning

Gonadorelin axis preservation refers to clinical strategies focused on maintaining the functional integrity of the Hypothalamic-Pituitary-Gonadal (HPG) axis, particularly the pulsatile release of Gonadotropin-Releasing Hormone (GnRH), also known as Gonadorelin. This preservation is paramount in hormonal interventions to prevent the suppression or atrophy of the body’s natural hormone production capacity, a common side effect of exogenous hormone administration. Sustaining the natural rhythm of this axis is critical for long-term reproductive health, fertility, and overall endocrine homeostasis. This is a primary goal in optimizing hormone replacement therapy protocols.