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Gonadal Steroid Sufficiency

Meaning

Gonadal Steroid Sufficiency is the optimal physiological state where the production and circulating concentrations of sex hormones, including testosterone, estrogen, and progesterone, produced by the gonads (ovaries or testes), are adequate for robust systemic function. This sufficient hormonal milieu is critical for maintaining healthy bone mineral density, supporting muscle mass, regulating libido, stabilizing mood, and promoting cardiovascular health. It represents the functional ideal for the hypothalamic-pituitary-gonadal (HPG) axis. Clinical interventions aim to restore or maintain this level of sufficiency to support long-term health and quality of life.