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Gonadal Steroid Signaling

Meaning

Gonadal steroid signaling encompasses the complex biochemical communication network mediated by sex hormones—primarily testosterone, estrogen, and progesterone—that originate in the testes and ovaries. This system dictates the development of secondary sexual characteristics, regulates reproductive function, and exerts significant pleiotropic effects on bone density, cardiovascular health, mood, and cognitive function. The integrity of this signaling pathway, from hormone synthesis to receptor binding, is a critical determinant of systemic vitality and healthspan. Clinical assessment of this signaling provides the foundation for hormonal optimization therapies.