Clinical strategies aimed at maintaining or restoring adequate physiological concentrations of endogenous gonadal steroids, such as testosterone or estradiol, when natural production is insufficient or imbalanced. This support seeks to optimize downstream effects on bone density, muscle mass, mood, and metabolic health. It is a targeted therapeutic approach within endocrinology.
Origin
Gonadal refers to the primary source of sex steroids, while support implies providing assistance or augmentation to a compromised biological function. This concept reflects an active intervention in the endocrine milieu.
Mechanism
Support mechanisms involve administering exogenous hormones or employing pharmaceutical agents that stimulate endogenous production, like SERMs or aromatase inhibitors, depending on the underlying pathology. The goal is to achieve levels that optimize receptor occupancy and downstream signaling in target tissues, thereby ameliorating symptoms associated with hypoandrogenism or hypoestrogenism.
Peptide therapies enhance stress resilience by physiologically optimizing hormonal axes and modulating cellular pathways for improved adaptation and recovery.
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