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Gonadal Hormone Decline

Meaning

The progressive, age-related reduction in the production and circulating levels of sex steroid hormones, primarily testosterone, estrogen, and progesterone, secreted by the testes in men and the ovaries in women. This physiological phenomenon, encompassing andropause and menopause, leads to profound systemic changes affecting musculoskeletal, cardiovascular, and cognitive health. It is a hallmark of reproductive senescence and a key focus in hormonal longevity medicine.