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Gonadal Axis Support

Meaning

Gonadal Axis Support refers to clinical interventions specifically designed to maintain or enhance the function of the Hypothalamic-Pituitary-Gonadal (HPG) axis, the primary regulatory loop for sex hormone production and gametogenesis. This support is often crucial in patients undergoing exogenous hormone therapy, where the introduction of external hormones can suppress the body’s natural production via negative feedback. The goal is to prevent or reverse central suppression, ensuring the testes or ovaries retain their capacity for endogenous hormone and gamete production. This therapeutic strategy is central to managing fertility and endocrine health during and after certain treatments.