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Gonadal Axis Fidelity

Meaning

The state of precise, robust, and responsive communication and function within the Hypothalamic-Pituitary-Gonadal (HPG) axis, ensuring the optimal pulsatile release of Gonadotropin-Releasing Hormone (GnRH), Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH), and the subsequent appropriate production of sex steroids. Fidelity in this context signifies the HPG axis’s ability to maintain its intended, youthful pattern of signaling and response, which is crucial for reproductive, bone, and systemic health. Loss of this fidelity is a key hallmark of reproductive and hormonal aging.