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Gonadal Aging Trajectory

Meaning

The Gonadal Aging Trajectory describes the predictable, yet individually variable, pattern of decline in the function of the ovaries and testes over the lifespan, leading to reduced sex steroid and gamete production. This process encompasses female menopause and male andropause, representing a systemic shift in the hypothalamic-pituitary-gonadal (HPG) axis. Understanding an individual’s unique trajectory is clinically essential for proactive hormonal health interventions aimed at mitigating age-related symptoms and preserving quality of life. This trajectory is influenced by genetic, lifestyle, and environmental factors.