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GnRH Secretion Fall

Meaning

A measurable reduction in the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus, a critical neuroendocrine event that serves as the master regulator of the Hypothalamic-Pituitary-Gonadal (HPG) axis. This fall in secretion directly results in diminished downstream signaling to the pituitary gland, leading to reduced production of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). Clinically, this is a key factor in reproductive senescence and hypogonadism.