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GnRH Receptors in Brain

Meaning

GnRH Receptors in the Brain are specific binding sites for Gonadotropin-Releasing Hormone (GnRH) found not only in the pituitary gland but also distributed throughout various non-pituitary regions of the central nervous system. These receptors mediate the effects of GnRH beyond its classical role in regulating reproductive function. Their presence suggests GnRH and its analogs play a direct role in neuroendocrine processes, influencing behavior, mood, cognition, and potentially neuroprotection. Understanding the function of these extra-pituitary receptors is critical for developing therapies that target the brain-gonadal axis for non-reproductive indications.