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GnRH Pulse Regulation

Meaning

GnRH Pulse Regulation refers to the precise, pulsatile release pattern of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamic neurons into the pituitary portal circulation, which is absolutely essential for normal reproductive function. The frequency and amplitude of these pulses dictate the differential secretion of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) from the anterior pituitary. Alterations in GnRH pulse frequency, which can be influenced by metabolic and stress hormones, are a common cause of reproductive disorders in both men and women. Maintaining this kinetic precision is central to the integrity of the Hypothalamic-Pituitary-Gonadal (HPG) axis.